Treatment options for people with inhibitors
Prophylaxis or treatment of bleeds in people with inhibitors (PWI) is more difficult than in people without inhibitors. While a number of treatment options are available for PWI, choosing the optimal one depends on many factors, including the inhibitor titer, the site and severity of the bleed and whether a patient is about to undergo immune tolerance induction (ITI) therapy.
Currently, bypassing agents are the mainstay of prophylaxis and treatment of bleeds in people with inhibitors. Available bypassing agents, whose role is to work around inhibitors to promote clotting, are activated prothrombin complex concentrate (aPCC) and recombinant activated factor VII (rVIIa). Individuals with inhibitors may respond differently to each product, so it is desirable to have access to both.
Immune tolerance induction (ITI) therapy
ITI therapy offers an opportunity to eliminate inhibitors and return to standard treatments (such as prophylaxis with clotting factor concentrates), which become effective again upon disappearance of clotting factor-neutralizing antibodies. The therapy is demanding and involves frequent infusions of the deficient clotting factor over an extended period of time – months or even years – and could prompt the immune system to stop seeing the infused clotting factor as a danger and wind down the inhibitor release.
High-dose factor concentrate infusions
In low responders or high responders with currently low inhibitor titers, bleeds may be effectively treated with high doses of clotting factor concentrates. However, in the latter group this intervention will provoke a rise in the inhibitor titer in a matter of several days and will thereafter no longer work, requiring a switch to bypassing agents.
Plasmapheresis allows to quickly reduce inhibitor titer in the patient’s plasma, which allows a temporary use of clotting factor concentrates to control bleeding before the inhibitor titer builds back up. The method requires specialised equipment that takes blood out of the patient’s body to separate the plasma from the blood cells and extract the inhibitor from it. Therefore, plasmapheresis is usually only done before surgery or when bleeding cannot be controlled using bypassing agents.
Tranexamic acid is an antifibrinolytic drug, which keeps the blood clot from breaking down and thus lowers the risk that bleeding will resume. Tranexamic acid does not stop the bleeding per se, so it cannot be used as a stand-alone therapy to control bleeding. However, it is a useful additional therapy, particularly in external bleedings from mucous membranes. It should not be used in combination with aPCC.